SwRI will be exhibiting at the Chemical and Biological Defense Science and Technology (CBD S&T) Conference, booth no. 211.
Southwest Research Institute (SwRI), headquartered in San Antonio, Texas, is an independent, nonprofit applied research and development organization that provides a variety of scientific solutions for government and industry. Our multidisciplinary nature allows us to rapidly assemble diverse teams to tackle problems and develop innovative solutions to improve human health and safety.
SwRI offers comprehensive drug discovery services that include high-throughput in silico target-based design, analog synthesis, in vitro assays, quantitative structure activity relationships (QSAR) analysis, and lead synthesis for preclinical toxicology. Once a lead candidate has been identified, SwRI offers comprehensive support of chemistry manufacturing controls (CMC) development services for small molecules and biologics that include process development, analytical development, and CGMP production in our FDA-registered (1614272) facilities. SwRI specializes in oral, parenteral, topical, and dermal dosage forms and can adapt formulations to provide extended/sustained release profiles to suit our clients' needs.
Please join us for our poster session:
Wednesday, Dec. 4
5:00 p.m. – 7:00 p.m.
“Discovery and Development of Filovirus Inhibitors: Managing Off-Target Risk of Sodium Channel Block with Pharmacophore Modeling,” Mariavictoria Moreno
Our medicinal chemistry efforts aim to reduce off-target effects from early-stage compounds and enhance the drug-likeness of broad-spectrum small molecule glycoprotein inhibitors targeting filoviruses. This investigation focused on developing a counter-screening model based on bioactivity data from state-dependent sodium channel inhibitors. We aimed to improve the safety profile of these novel filovirus inhibitors by applying this predictive ligand-based pharmacophore model to avoid sodium channel inhibition.
For more information, please contact Nadean Gutierrez.