Our medicinal chemistry team provides integrated services including drug design, library synthesis, in vitro assays, lead development and optimization, and scale-up synthesis to support a variety of targets. We offer computational drug design and optimization from initial virtual library screening and binding site search to scale-up synthesis.
Computational Drug Design and Optimization Services
- In silico protein docking and simulation with proprietary Rhodium™ platform
- Virtual library screening
- Allosteric binding site search
- Pharmacophore modeling and other QSAR techniques
Synthetic Services
- Small molecule library synthesis
- Automated small molecule synthesis
- Mass guided purification
- Physicochemical characterization
- Prodrug development
- Hit to lead assessment
- Lead optimization
- Biomolecule conjugation – linker development, toxins, others
- Protein conjugates
- High potency compounds
Scale-up Synthesis
- Synthesis of lead compound and backup
- Stability testing (solid state and solution)
- Salt forms
- Analytical method development
- Metabolite synthesis