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Medicinal Chemistry

Our medicinal chemistry team provides integrated services including drug design, library synthesis, in vitro assays, lead development and optimization, and scale-up synthesis to support a variety of targets. We offer computational drug design and optimization from initial virtual library screening and binding site search to scale-up synthesis.

Computational Drug Design and Optimization Services

  • In silico protein docking and simulation with proprietary Rhodium platform
  • Virtual library screening
  • Allosteric binding site search
  • Pharmacophore modeling and other QSAR techniques

Synthetic Services

  • Small molecule library synthesis
  • Automated small molecule synthesis
  • Mass guided purification
  • Physicochemical characterization
  • Prodrug development
  • Hit to lead assessment
  • Lead optimization
  • Biomolecule conjugation – linker development, toxins, others
  • Protein conjugates
  • High potency compounds

Scale-up Synthesis

  • Synthesis of lead compound and backup
  • Stability testing (solid state and solution)
  • Salt forms
  • Analytical method development
  • Metabolite synthesis